Mammary Gland Development in Transforming Growth Factor Beta1 Null Mutant Mice: Systemic and Epithelial Effects1
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چکیده
منابع مشابه
Laminar Organization of Cerebral Cortex in Transforming Growth Factor Beta Mutant Mice
Transforming growth factor betas (TGF?s) are one of the most widespread and versatile cytokines. The three mammalian TGF? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. Functions of TGF?s has a wide spectrum ranging from regulating cell proliferation and differ...
متن کاملTitle: the Mechanistic Basis for Sexual Dysfunction in Male Transforming Growth Factor Beta1 Null Mutant Mice Short Title: Sexual Dysfunction in Tgfb1 Null Mice
1 The cytokine transforming growth factor beta 1 (TGFB1) is implicated in male sexual 2 function. Previous behavioral studies show that Tgfb1 null mutant mice mount and 3 display limited intromission behavior with receptive females, but are unable to complete 4 successful copulation. The studies presented here explore the physiological basis for 5 sexual dysfunction in Tgfb1 null mutant males. ...
متن کاملThe recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
متن کاملTransforming Growth Factor-β Regulator SnoN Modulates Mammary Gland Branching Morphogenesis, Postlactational Involution, and Mammary Tumorigenesis
Authors' A University Medicine Canada Note: Curr of Californi Correspon Cell Biolog CA 94720. berkeley.ed
متن کاملTransforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesis.
SnoN is an important negative regulator of transforming growth factor-beta (TGF-beta) signaling that was originally identified as a transforming oncogene in chicken embryonic fibroblasts. Both pro-oncogenic and antioncogenic activities of SnoN have been reported, but its function in normal epithelial cells has not been defined. In the mouse mammary gland, SnoN is expressed at relatively low lev...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2008
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.107.067272